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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 1
1990 2
1991 2
1992 1
1994 1
1995 3
1996 2
1997 2
1998 11
1999 8
2000 9
2001 7
2002 9
2003 10
2004 10
2005 2
2006 8
2007 10
2008 11
2009 8
2010 15
2011 22
2012 19
2013 19
2014 19
2015 22
2016 15
2017 16
2018 18
2019 16
2020 15
2021 15
2022 22
2023 15
2024 4

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327 results

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Page 1
Interleukin-1 receptor accessory protein (IL-1RAP): A magic bullet candidate for immunotherapy of human malignancies.
Zarezadeh Mehrabadi A, Shahba F, Khorramdelazad H, Aghamohammadi N, Karimi M, Bagherzadeh K, Khoshmirsafa M, Massoumi R, Falak R. Zarezadeh Mehrabadi A, et al. Crit Rev Oncol Hematol. 2024 Jan;193:104200. doi: 10.1016/j.critrevonc.2023.104200. Epub 2023 Nov 21. Crit Rev Oncol Hematol. 2024. PMID: 37981104 Review.
This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and si …
This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 re …
The family of the interleukin-1 receptors.
Boraschi D, Italiani P, Weil S, Martin MU. Boraschi D, et al. Immunol Rev. 2018 Jan;281(1):197-232. doi: 10.1111/imr.12606. Immunol Rev. 2018. PMID: 29248002 Review.
IL-1 ligands bind to the extracellular portion of their ligand-binding receptor chain. For signaling to take place, a non-binding accessory chain is recruited into a heterotrimeric complex. The intracellular approximation of the Toll-IL-1-receptor (TIR) domai …
IL-1 ligands bind to the extracellular portion of their ligand-binding receptor chain. For signaling to take place, a non-binding …
Multifaceted roles of TAX1BP1 in autophagy.
White J, Suklabaidya S, Vo MT, Choi YB, Harhaj EW. White J, et al. Autophagy. 2023 Jan;19(1):44-53. doi: 10.1080/15548627.2022.2070331. Epub 2022 May 9. Autophagy. 2023. PMID: 35470757 Free PMC article. Review.
In addition to these canonical autophagy receptor functions, TAX1BP1 can also exert multiple accessory functions that influence the biogenesis and maturation of autophagosomes. In this review, we will discuss and integrate recent findings related to the autophagy fu …
In addition to these canonical autophagy receptor functions, TAX1BP1 can also exert multiple accessory functions that influenc …
Biologic basis for interleukin-1 in disease.
Dinarello CA. Dinarello CA. Blood. 1996 Mar 15;87(6):2095-147. Blood. 1996. PMID: 8630372 Free article. Review.
To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how production of the different members of the IL-1 family is controlled, the various biologic activities of IL-1, the distinct and various functions o …
To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how product …
IL-1, IL-18, and IL-33 families of cytokines.
Arend WP, Palmer G, Gabay C. Arend WP, et al. Immunol Rev. 2008 Jun;223:20-38. doi: 10.1111/j.1600-065X.2008.00624.x. Immunol Rev. 2008. PMID: 18613828 Review.
The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure, and signal transduction pathways utilized. ...The IL-18 family also contains a specific inhibitor, the IL-18-binding protein (IL-18 …
The interleukin-1 (IL-1), IL-18, and IL-33 families of cytokines are related by mechanism of origin, receptor structure …
Treating inflammation by blocking interleukin-1 in humans.
Dinarello CA, van der Meer JW. Dinarello CA, et al. Semin Immunol. 2013 Dec 15;25(6):469-84. doi: 10.1016/j.smim.2013.10.008. Epub 2013 Nov 23. Semin Immunol. 2013. PMID: 24275598 Free PMC article. Review.
In common conditions such as heart failure and gout arthritis, IL-1 blockade can be effective therapy. Three IL-1blockers have been approved: the IL-1 receptor antagonist, anakinra, blocks the IL-1 receptor and therefore reduces the activity of IL-1alpha and IL-1bet …
In common conditions such as heart failure and gout arthritis, IL-1 blockade can be effective therapy. Three IL-1blockers have been approved …
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
Zhang Y, Chen X, Wang H, Gordon-Mitchell S, Sahu S, Bhagat TD, Choudhary G, Aluri S, Pradhan K, Sahu P, Carbajal M, Zhang H, Agarwal B, Shastri A, Martell R, Starczynowski D, Steidl U, Maitra A, Verma A. Zhang Y, et al. J Hematol Oncol. 2022 May 23;15(1):70. doi: 10.1186/s13045-022-01286-4. J Hematol Oncol. 2022. PMID: 35606824 Free PMC article.
Advanced pancreatic ductal adenocarcinoma (PDAC) is usually an incurable malignancy that needs newer therapeutic targets. Interleukin-1 receptor accessory protein (IL1RAP) is an innate immune mediator that regulates activation of pro-inflammator …
Advanced pancreatic ductal adenocarcinoma (PDAC) is usually an incurable malignancy that needs newer therapeutic targets. Interleukin …
Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.
Cao K, Liu Z, Liu J, Hu Q, Shan W, Hu B, Shi H, Zhang B. Cao K, et al. J Cancer Res Clin Oncol. 2023 Dec;149(18):16247-16260. doi: 10.1007/s00432-023-05367-w. Epub 2023 Sep 12. J Cancer Res Clin Oncol. 2023. PMID: 37700160
BACKGROUND: Constitutive photomorphogenic protein 1 (COP1) plays a pivotal role in the development and progression of several human cancers and is reported to be upregulated in liver cancer. ...COP1 overexpression promoted proliferation of liver cancer cells, while …
BACKGROUND: Constitutive photomorphogenic protein 1 (COP1) plays a pivotal role in the development and progression of several huma …
The interleukin-1 receptor family.
Boraschi D, Tagliabue A. Boraschi D, et al. Semin Immunol. 2013 Dec 15;25(6):394-407. doi: 10.1016/j.smim.2013.10.023. Epub 2013 Nov 15. Semin Immunol. 2013. PMID: 24246227 Review.
With the exception of the IL-1 and IL-36 receptor antagonists, a second chain, termed the "accessory chain", is recruited, forms a heterotrimetic complex with the ligand binding chain and the ligand, and signal transduction is initiated. Each ligand binding or ac …
With the exception of the IL-1 and IL-36 receptor antagonists, a second chain, termed the "accessory chain", is recruited, for …
Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation.
Mulholland M, Depuydt MAC, Jakobsson G, Ljungcrantz I, Grentzmann A, To F, Bengtsson E, Jaensson Gyllenbäck E, Grönberg C, Rattik S, Liberg D, Schiopu A, Björkbacka H, Kuiper J, Bot I, Slütter B, Engelbertsen D. Mulholland M, et al. Cardiovasc Res. 2024 Apr 2:cvae046. doi: 10.1093/cvr/cvae046. Online ahead of print. Cardiovasc Res. 2024. PMID: 38563353
AIMS: The interleukin-1 receptor accessory protein (IL1RAP) is a co-receptor required for signalling through the IL-1, IL-33, and IL-36 receptors. Using a novel anti-IL1RAP-blocking antibody, we investigated the role of IL1RAP in atherosc …
AIMS: The interleukin-1 receptor accessory protein (IL1RAP) is a co-receptor required for signalli …
327 results